Saturday, August 1, 2009

Memories Return from Depths of Advanced Alzheimer’s for Mice Given Neural Stem Cells

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SeniorJournal.com

Alzheimer's, Dementia & Mental Health

The stem cells secreted a protein causing new neurites, strengthening and increasing the number of connections between neurons -

It is one of those things you might wish for if given just one wish – the recovery of memory for those suffering with advanced Alzheimer’s disease. Scientists at UC Irvine say they have made it happen using neural stem cells with mice.

The mice, genetically engineered to have Alzheimer's, performed markedly better on memory tests a month after mouse neural stem cells were injected into their brains.

The stem cells secreted a protein that created more neural connections, improving cognitive function and raising hopes of a potential treatment for the leading cause of dementia that afflicts 5.3 million people in the U.S.

Essentially, the cells were producing fertilizer for the brain," said Frank LaFerla, director of UCI's Institute for Memory Impairments & Neurological Disorders, or UCI MIND, and co-author of the study, which appears online the week of July 20 in the Proceedings of the National Academy of Sciences.

Lead author Mathew Blurton-Jones, LaFerla and colleagues worked with older mice predisposed to develop brains lesions called plaques and tangles that are the hallmarks of Alzheimer's.

To learn how the stem cells worked, the scientists examined the....read all of Memories Return from Depths of Advanced Alzheimer’s for Mice Given Neural Stem Cells

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